ÀÖÓã¹ÙÍøApp

ÄúµÄλÖÃ: Ê×Ò³Ñо¿ÉúÅàÑø˶ʿÉúµ¼Ê¦¼ò½é
ÀÖÓã¹ÙÍøApp-09-02 10:57:22  ¸ß±ó

×Ö³ÉÍ¥ ½ÌÊÚ

×Ö³ÉÍ¥£¬ÄУ¬ÒÍ×壬1986Äê03ÔÂ20ÈÕ³öÉú£¬²©Ê¿£¬½ÌÊÚ£¬Ë¶Ê¿Ñо¿Éúµ¼Ê¦¡£ÔÆÄÏÊ¡·ïÇìÏØÈË£¬Öй²µ³Ô±¡£2015Äê±ÏÒµÓÚÔÆÄÏ´óѧֲÎïѧרҵ£¬»ñµÃÀíѧ²©Ê¿Ñ§Î»¡£ÏÖ¹¤×÷ÓÚÔÆÄÏÅ©Òµ´óѧ?ÆÕ¶ý²èѧ½ÌÓý²¿ÖصãʵÑéÊÒ¡£

Ö÷½²¿Î³Ì£º±¾¿ÆÆÕͨ»¯Ñ§£¬Óлú»¯Ñ§£¨B£©

Ñо¿·½Ïò£º

1.ÐÂÒ©Ïà¹ØÑз¢:ÒÔÌìÈ»À´Ô´µÄ¿¹Ö×Áö»îÐÔ·Ö×ÓΪ»ù´¡£¬Õë¶ÔÐԵؽøÐнṹÓÅ»¯£¬Îª¸Ã·Ö×ӵijÉÒ©ÐÔÑо¿½øÐÐ̽Ë÷¡£

2.¸ßÔ­ÌØɫʳƷ¹¦ÄÜÒò×ӵĿª·¢ÓëÀûÓÃ:ÀûÓÃʳƷ»¯Ñ§»ù´¡£¬ÍÚ¾ò¸ßÔ­ÌØɫʳƷÖеŦÄÜÒò×Ó²¢¶ÔÆä½øÐнøÒ»²½µÄ¿ª·¢ÓëÀûÓá£

3.²èÒ¶¾«Éî¼Ó¹¤ÓëÆ·ÖÊ»¯Ñ§Ñо¿:£¨1£©Ó¦ÓÃÏÖ´úÉúÎï¿Æѧ¼¼Êõ½øÐвèÒ¶µÄ¾«Éî¼Ó¹¤Óë×ÛºÏÀûÓÃ;£¨2£©ÔËÓû¯Ñ§¡¢É«Æ×ѧ¼°ÏÖ´ú·ÖÎöÒÇÆ÷É豸Ñо¿ºì²è¡¢ÆÕ¶ý²èµÄÆ·ÖÊ»¯Ñ§¼°ÖÊÁ¿±ê×¼¡£

Ö÷³Ö¼°²Î¼Ó¿ÎÌ⣺

1.Ö÷³Ö¹ú¼Ò×ÔÈ»¿ÆѧµØÇø»ù½ðÏîÄ¿¡°ÐÂÐÍÌúƤʯõúËØÀà΢¹Üµ°°×

ÒÖÖƼÁµÄÍÚ¾ò¼°×÷ÓûúÀíÑо¿¡±£¨C020601£©£¬¾­·Ñ40.0ÍòÔª£¬Æðֹʱ¼ä£º2020.01¨CÀÖÓã¹ÙÍøApp.12¡£

2.Ö÷³Ö¹ú¼Ò×ÔÈ»¿Æѧ»ù½ðÇàÄêÏîÄ¿¡°±íûʳ×Ó¶ù²èËØûʳ×ÓËáõ¥

£¨EGCG£©Ñõ»¯ÎïµÄÑ¡ÔñÐԺϳÉ¡¢·ÖÀë¼°¿¹Ö×Áö»îÐÔÑо¿¡±£¨21602196£©£¬¾­·Ñ20.0ÍòÔª£¬Æðֹʱ¼ä£º2017.01¨C2019.12¡£

3.Ö÷³ÖÔÆÄÏÊ¡Å©ÒµÁªºÏרÏîÃæÉÏÏîÄ¿¡°¶ù²èËØÀ໯ºÏÎïµÄ»¯Ñ§ÐÞ

ÊζÔÆäÉúÎïÀûÓöÈÆÁÕϵÄ×÷Óü°»úÀíÑо¿¡±£¨2017FG001£¨-046£©£©£¬¾­·Ñ10.0ÍòÔª£¬Æðֹʱ¼ä£º2017.09¨C2020.08¡£

4.Ö÷³ÖÔÆÄÏÊ¡×ÔÈ»¿Æѧ»ù½ðÇàÄêÏîÄ¿¡°»¯Ñ§Ñ¡ÔñÐÔEGCGżÁªÑõ

»¯²úÎïµÄºÏ³É¼°¿¹Ö×Áö»îÐÔÑо¿¡±£¨2017FD084£©£¬¾­·Ñ5.0ÍòÔª£¬Æðֹʱ¼ä£º2017.06¨C2020.05¡£

5.Ö÷³ÖÔÆÄÏÅ©Òµ´óѧÇàÄê»ù½ðÏîÄ¿¡°±íûʳ×Ó¶ù²èËØûʳ×ÓËáõ¥

ÌÇÜÕÎïµÄºÏ³É¼°¹¦ÄÜ»îÐÔÑо¿¡±£¨2015ZR08£©£¬¾­·Ñ5.0ÍòÔª£¬Æðֹʱ¼ä£º2016.01¨C2018.12¡£

6.Ö÷³ÖÔÆÄÏÅ©Òµ´óѧ²©Ê¿¿ÆÑÐÆô¶¯»ù½ðÏîÄ¿¡°±íûʳ×Ó¶ù²èËØû

ʳ×ÓËáõ¥µÄ·Ö×ÓÐÞÊμ°»îÐÔÑо¿¡±£¨A2002396£©£¬¾­·Ñ5.0ÍòÔª£¬Æðֹʱ¼ä£º2016.01¨C2019.12¡£

7.²ÎÓëÊ¡ÖØ´ó¿Æ¼¼¼Æ»®£¨ÉúÎïÒ½Ò©£©¡°Ê¯õúËØSÑÜÉúÎïÖÎÁÆ°×Ѫ²¡

1ÀàÐÂÒ©µÄÁÙ´²Ç°Ô¤Ñо¿¡±£¨2017ZF003¨D01£©£¬¾­·Ñ600.0ÍòÔª£¬Æðֹʱ¼ä£º2017.01¨C2019.12¡£

8.²ÎÓëÊ¡ÖØ´ó¿Æ¼¼£¨ÉúÎïÒ½Ò©£©¡°ÌúƤʯõú¸´·½´Ù½øÌÇÄò²¡ÉË¿ÚÓú

ºÏ5ÀàÐÂÒ©µÄÁÙ´²Ç°Ô¤Ñо¿¡±£¨2017ZF003¨D02£©£¬¾­·Ñ650.0ÍòÔª£¬Æðֹʱ¼ä£º2017.01¨C2019.12¡£

9.²ÎÓëÊ¡ÖØ´ó¿Æ¼¼£¨ÉúÎïÒ½Ò©£©¡°ÌúƤʯõú¸´·½Ôö¼Ó¹ÇÃܶȱ£½¡Ê³

Æ·Ñо¿¿ª·¢¡±£¨2017ZF003¨D03£©£¬¾­·Ñ1020.0ÍòÔª£¬Æðֹʱ¼ä£º2017.01¨C2019.12¡£

10.²ÎÓë¹ú¼Ò×ÔÈ»¿Æѧ»ù½ðµØÇøÏîÄ¿¡°Ó¦ÓÃÃâÒß×éÖ¯»¯Ñ§·¨¶ÔÔÆÄÏ

²èÊ÷ÖÐõ¥ÐͶù²èËØÑÇϸ°ûˮƽµÄ¶¨Î»Ñо¿¡±£¨C161104£©£¬¾­·Ñ36.0ÍòÔª£¬Æðֹʱ¼ä£º2018.01¨C2021.12¡£

11.²ÎÓë¹ú¼Ò×ÔÈ»¿Æѧ»ù½ðÇàÄêÏîÄ¿¡°ÔÆÄÏÃÀÀöÉÖÒ©Ö÷Òª´ÎÉú´úл

²úÎï×÷ÓÃÓÚÍʺÚËØÊÜÌå»îÐԳɷּ°¹¹Ð§¹ØϵÑо¿¡±£¨31600279£©£¬¾­·Ñ20.0ÍòÔª£¬Æðֹʱ¼ä£º2017.01¨C2019.12¡£

12.²ÎÓëÔÆÄÏÊ¡×ÔÈ»¿Æѧ»ù½ðÃæÉÏÏîÄ¿¡°ÉúÎïËؼ°ÌÇÜÕ»¯ÐÞÊιí¾Ê

¶¾ËØÀ໯ºÏÎïµÄ¿¹Ö×ÁöÒ©ÎïÑз¢¡±£¨Y538521261£©£¬¾­·Ñ10.0ÍòÔª£¬Æðֹʱ¼ä£º2015.08¨C2018.07¡£

13.²ÎÓëÖйú¿ÆÀÖÓã¹ÙÍøAppÖ²ÎﻯѧÓëÎ÷²¿Ö²Îï×ÊÔ´³ÖÐøÀûÓùú¼ÒÖصã

ʵÑéÊÒ¿ª·Å¿ÎÌâÏîÄ¿¡°¹í¾Ê¶¾ËصĽṹÐÞÊÎÓë°ÐÏò¿¹°©»îÐÔÑо¿¡±(Y17529211Z1)£¬¾­·Ñ8.0ÍòÔª£¬Æðֹʱ¼ä£º2010.12¨C2013.09¡£

14.²ÎÓëÍƹã·þÎñÏîÄ¿¡°ÆÕ¶ý²èµÄ²úÆ·¿ª·¢ÓëÌåÑ顱£¬¾­·Ñ100.0Íò

Ôª£¬Æðֹʱ¼ä£º2013.12¨C2015.12¡£

15.²ÎÓëÍƹã·þÎñÏîÄ¿¡°ºì²èµÄ²úÆ·¿ª·¢ÓëÌåÑ顱£¬¾­·Ñ100.0ÍòÔª£¬

Æðֹʱ¼ä£º2013.12¨C2015.12¡£

´ú±íÐԳɹû£º

½üÄêÀ´£¬ÔÚ¹úÄÚÍâÆÚ¿¯·¢±íÂÛÎÄ50Óàƪ£¬ÆäÖÐSCIÊÕ¼34ƪ£¬ÉêÇë¹ú¼Ò·¢Ã÷רÀû3Ïî¡£

[1]          Huanhuan Xu#, Titi Liu#, Jin Li, Jing Xu, Fei Chen, Lihong Hu, Banglei Zhang, Chengting Zi*, Xuanjun Wang*, Jun Sheng*. An (-)-epigallocatechin-3-gallate oxidation derivative inhibits RANKL-induced osteoclastogenesis by down-regulating NFATc1 and c-Fos expression in RAW 264.7 cells. Biomed. Pharmacother. 2019, 118 (109237) 1¨C9.

[2]      Chengting Zi#, Liu Yang#, Bang-Lei Zhang, Yan Li, Zhong-Tao Ding, Zi-Hua Jiang*, Jiang-Miao Hu*, Jun Zhou. Synthesis and cytotoxicities of novel podophyllotoxin xyloside derivatives. Nat. Prod. Comm. 2019, 7: 1¨C6.

[3]      Jing Wang#, Yuna Wang#, Peiyuan Sun, Chengting Zi*, Xuanjun Wang*, Jun Sheng*. Glucosylated epigallocatechin gallate (EGCG) derivatives combined with EGFR tyrosine kinase inhibitor overcome resistance in EGFR T790M mutant lung cancer. BJSTR, 2019, 18 (2): 1¨C6.

[4]          Chengting Zi, Liu Yang, Zihua Jiang, Jiangmiao Hu*, Xuan-Jun Wang*, Jun Sheng*. Study of Dimer Lead Compounds via Triazole Rings as Novel Potential Antitumor Agents. BJSTR, 2019, 6 (5): 1¨C3.

[5]      Chengting Zi#, Yingsheng Gao#, Liu Yang#, Shuyun Feng, Yue Huang, Li Sun, Yi Jin, Fengqing Xu, Fawu Dong, Yan Li, Zhongtao Ding, Jun Zhou, Zihua Jiang*, Shengtao Yuan*, Jiangmiao Hu*. Design, synthesis, and biological evaluation of novel biotinylated podophyllotoxin derivatives as potential antitumor agents. Fron. Chem. 2019, 7, 1¨C14. doi: 10.3389/fchem.2019.00434

[6]      Chengting Zi#, Liu Yang#, Fawu Dong, Qinghua Kong, Zhongtao Ding, Jun Zhou, Zihua Jiang*, Jiangmiao Hu*. Synthesis and antitumor activity of camptothecin-4¦Â-triazolopodophyllotoxin conjugates. Nat. Prod. Res. 2019 12: 1¨C9.

[7]      Chengting Zi#, Liu Yang#, Fengqing Xu, Fawu Dong, Ruijing Ma, Yan Li, Jun Zhou, Zhongtao Ding, Zihua Jiang*, Jiangmiao Hu*. Synthesis and antitumor activity of biotinylated camptothecin derivatives as potent cytotoxic agents. Bioorg. Med. Chem. Lett. 2019, 29: 234¨C237.

[8]      Chengting Zi#, Liu Yang#, Fengqing Xu, Fawu Dong, Dan Yang, Yan Li, Zhongtao Ding, Jun Zhou, Zihua Jiang*, Jiangmiao Hu*. Synthesis and anticancer activity of dimeric podophyllotoxin derivatives. Drug Des. Dev. Ther. 2018, 12, 3393¨C3406.

[9]      Qi Wang#, Chengting Zi#, Jing Wang, Yuna Wang, Yewei Huang, Xueqi Fu*, Xuanjun Wang*, Jun Sheng*. Dendrobium Officinale orchid extract prevents ovariectomy-induced osteoporosis in vivo and inhibitis RANKL-induced osteoclast differentiation in vitro. Front. Pharmacol. 2018, 8, 966.

[10]  Jing Wang#, Han Tang#, Bo Hou, Pan Zhang, Qi Wang, Banglei Zhang, Yewei Huang, Ya Wang, Zeming Xiang, Chengting Zi*, Xuanjun Wang*, Jun Sheng*. Synthesis, antioxidant activity, and density functional theory study of catechin derivatives. RSC Advances 2017, 7, 54136¨C54141.

[11]  Chengting Zi#, Liu Yang#, Wei Gao, Yan Li, Jun Zhou, Zhongtao Ding, Jiangmiao Hu*, Zihua Jiang*. Click Glycosylation for the Synthesis of 1,2,3-Triazole-Linked Picropodophyllotoxin Glycoconjugates and Their Anticancer Activity. ChemistrySelect. 2017, 2 (18): 5038¨C5044.

[12]       Xin Zhang, Jing Wang, Jiangmiao Hu, Yewei Huang, Xiaoyun Wu, Chengting Zi*, Xuanjun Wang*, Jun Sheng*. Synthesis and Biological Testing of Novel Glucosylated Epigallocatechin Gallate (EGCG) Derivatives. Molecules, 2016, 21, 619¨C628.

[13]       Chengting Zi, Dan Yang, Fawu Dong, Gentao Li, Yan Li, Zhongtao Ding, Jun Zhou, Zihua Jiang*, Jiangmiao Hu*. Synthesis and antitumor activity of novel per-butyrylated glycosides of podophyllotoxin and its derivatives. Bioorg. Med. Chem. 2015, 23 (7): 1437¨C1446.

[14]       Chengting Zi, Zhenhua Liu, Gentao Li, Yan Li, Jun Zhou, Zhongtao Ding*, Jiangmiao Hu*, Zihua Jiang*. Synthesis, and Cytotoxicity of Perbutyrylated Glycosides of 4¦Â-Triazolopodophyllotoxin Derivatives. Molecules, 2015, 20 (2): 3255¨C3280.

[15]       Chengting Zi, Gentao Li, Yan Li, Jun Zhou, Zhongtao Ding, Zihua Jiang*, Jiangmiao Hu*. Synthesis and anticancer activity of 4¦Â-triazole-podophyllotoxin glycosides. Nat. Prod. Bioprospect. 2015, 5, 83¨C90.

[16]       Chengting Zi, Fengqing Xu, Gentao Li, Yan Li, Zhongtao Ding, Jun Zhou, Zihua Jiang*, Jiangmiao Hu*. Synthesis and Anticancer Activity of Glucosylated Podophyllotoxin Derivatives Linked via 4¦Â-Triazole Rings. Molecules, 2013, 18 (11): 13992¨C14012.

רÀû

[1]        ½¯×Ó»ª£¬×Ö³ÉÍ¥£¬ºú½­Ã磬ÖÜ¿¡£¬¶¡ÖÐÌΣ¬ÁõÓñÇ壬ÑîÁø£¬Ì·Ê˽Ü.¹í¾Ê¶¾ËØÌÇÜÕÎïºÍõ£»¯ÌÇÜÕÎï¼°ÆäÒ©Îï×éºÏÎïºÍÆäÖƱ¸·½·¨ÓëÓ¦Óã¬×¨Àû¹«¿ªºÅ£ºCN103570780A.

[2]        ½¯×Ó»ª£¬×Ö³ÉÍ¥£¬ºú½­Ã磬ÖÜ¿¡£¬¶¡ÖÐÌΣ¬ÁõÓñÇ壬ÑîÁø.ÉúÎïËØ-¹í¾Ê¶¾ËØõ¥»¯ÑÜÉúÎï¼°ÆäÒ©Îï×éºÏÎïºÍÆäÖƱ¸·½·¨ÓëÓ¦Óã¬×¨Àû¹«¿ªºÅ£ºCN104098594A.

[3]        Ê¢¾ü£¬ÍõÐû¾ü£¬×Ö³ÉÍ¥£¬Íõ¾§£¬ÏòÔóÃô£¬»Æҵ࣬Íõæ«£¬ÎâÏþÔÆ£¬·½³çÒµ£¬Áõ¼Ñ£¬ÕŶ¬Ó¢£¬Íôçù£¬ÌÆêÏ£¬ÕÅ°ïÀÚ£¬ÍõÓñÄÈ.±íûʳ×Ó¶ù²èËØûʳ×ÓËáõ¥ÌÇÜÕÑÜÉúÎï¼°ÆäÓ¦Óã¬×¨Àû¹«¿ªºÅ£ºCN201810094218.6

 

 


Copyright © 2010-ÀÖÓã¹ÙÍøApp ÀÖÓã¹ÙÍøApp
ÀÖÓã¹ÙÍøAppÐÂÎÅͶ¸åÓÊÏ䣺ynauspxy@163.com
 
 

 

ÀÖÓã¹ÙÍøApp - £¨¼¯ÍÅ£©ÓÐÏÞ¹«Ë¾